With an ambitious schedule, MAPh stages four large exhibitions, including one major art prize, each year. The Bowness Photography Prize has emerged as an important annual survey of contemporary photography practice in Australia and one of the most prestigious prizes in the country. More recently, the MAPh Foundation has partnered with Kee Wong to establish the Wai Tang Commissioning Award; MAPh members also have the opportunity to enter the annual 'LOOK!' Prize.

A range of innovative and stimulating public programs and special events are held in conjunction with exhibitions, including artist talks, guided tours for schools and community groups, and concerts.

The original part of the MGA building was designed by internationally renowned architect Harry Seidler. It remains the only formal art gallery space designed by Seidler. Situated in landscaped grounds with a sculpture park, and stunning views of the Dandenong Ranges, MAPh occupies a landmark site once home to an early homestead.